Chapter 3. Molecular Radiation Biology
Judith Reindl
(1)
,
Ana Margarida Abrantes
(2)
,
Vidhula Ahire
(3)
,
Omid Azimzadeh
(4)
,
Sarah Baatout
(5)
,
Ans Baeyens
(6)
,
Bjorn Baselet
(5)
,
Vinita Chauhan
(7)
,
Fabiana da Pieve
(8)
,
Wendy Delbart
(9)
,
Caitlin Pria Dobney
(10)
,
Nina Frederike Jeppesen Edin
(11)
,
Martin Falk
(12)
,
Nicolas Foray
(13)
,
Agnès François
(14)
,
Sandrine Frelon
(15)
,
Udo S Gaipl
(16)
,
Alexandros G Georgakilas
(17)
,
Olivier Guipaud
(14)
,
Michael Hausmann
(18)
,
Anna Jelinek Michaelidesova
(12)
,
Munira Kadhim
(19)
,
Inês Alexandra Marques
(20)
,
Mirta Milic
(21)
,
Dhruti Mistry
(5)
,
Simone Moertl
(4)
,
Alegría Montoro
(22)
,
Elena Obrador
(22)
,
Ana Salomé Pires
(2)
,
Roel Quintens
(5)
,
Nicholas Rajan
(5)
,
Franz Rödel
(23)
,
Peter Rogan
(24)
,
Diana Savu
(25)
,
Giuseppe Schettino
(26)
,
Kevin Tabury
(27)
,
Georgia I Terzoudi
(28)
,
Sotiria Triantopoulou
(28)
,
Kristina Viktorsson
(29)
,
Anne-Sophie Wozny
(30)
1
Universität der Bundeswehr München [Neubiberg]
2 UC - Universidade de Coimbra = University of Coimbra [Portugal]
3 CDUT - Chengdu University of Technology
4 BfS - Bundesamt für Strahlenschutz - Federal Office for Radiation Protection
5 SCK-CEN - Belgian Nuclear Research Centre [Mol, Belgique]
6 UGENT - Universiteit Gent = Ghent University = Université de Gand
7 Health Canada
8 BIRA-IASB - Royal Belgian Institute for Space Aeronomy
9 Hôpital Universitaire de Bruxelles
10 University of Toronto
11 UiO - University of Oslo
12 CAS - Czech Academy of Sciences [Prague]
13 Inserm U1296 - Unité Ad Hoc INSERM 000008 "Radiations : Défense, Santé, Environnement" [Lyon]
14 IRSN/PSE-SANTE/SERAMED/LRMed - Laboratoire de Radiobiologie des expositions médicales
15 IRSN/PSE-ENV/SERPEN/LECO - Laboratoire d'écologie et d'écotoxicologie des radionucléides
16 Department of Radiation Oncology, University Hospital of Erlangen
17 NTUA - National Technical University of Athens [Athens]
18 Department of Virology,
19 Oxford Brookes University
20 Universidade do Porto = University of Porto
21 IMROH
22 University General Hospital of Valencia
23 Goethe University Frankfurt
24 UWO - University of Western Ontario
25 ISS - Institute of Space Science [Bucharest-Măgurele]
26 UNIS - University of Surrey
27 SCK-CEN - Centre d'Etude de l'Energie Nucléaire
28 IPC - Institute of Physical Chemistry "Demokritos"
29 Karolinska Institutet Science Park
30 IP2I Lyon - Institut de Physique des 2 Infinis de Lyon
2 UC - Universidade de Coimbra = University of Coimbra [Portugal]
3 CDUT - Chengdu University of Technology
4 BfS - Bundesamt für Strahlenschutz - Federal Office for Radiation Protection
5 SCK-CEN - Belgian Nuclear Research Centre [Mol, Belgique]
6 UGENT - Universiteit Gent = Ghent University = Université de Gand
7 Health Canada
8 BIRA-IASB - Royal Belgian Institute for Space Aeronomy
9 Hôpital Universitaire de Bruxelles
10 University of Toronto
11 UiO - University of Oslo
12 CAS - Czech Academy of Sciences [Prague]
13 Inserm U1296 - Unité Ad Hoc INSERM 000008 "Radiations : Défense, Santé, Environnement" [Lyon]
14 IRSN/PSE-SANTE/SERAMED/LRMed - Laboratoire de Radiobiologie des expositions médicales
15 IRSN/PSE-ENV/SERPEN/LECO - Laboratoire d'écologie et d'écotoxicologie des radionucléides
16 Department of Radiation Oncology, University Hospital of Erlangen
17 NTUA - National Technical University of Athens [Athens]
18 Department of Virology,
19 Oxford Brookes University
20 Universidade do Porto = University of Porto
21 IMROH
22 University General Hospital of Valencia
23 Goethe University Frankfurt
24 UWO - University of Western Ontario
25 ISS - Institute of Space Science [Bucharest-Măgurele]
26 UNIS - University of Surrey
27 SCK-CEN - Centre d'Etude de l'Energie Nucléaire
28 IPC - Institute of Physical Chemistry "Demokritos"
29 Karolinska Institutet Science Park
30 IP2I Lyon - Institut de Physique des 2 Infinis de Lyon
Ana Margarida Abrantes
- Fonction : Auteur
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Omid Azimzadeh
- Fonction : Auteur
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Ans Baeyens
- Fonction : Auteur
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Nicolas Foray
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Agnès François
- Fonction : Auteur
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Sandrine Frelon
- Fonction : Auteur
- PersonId : 1064192
- IdHAL : frelon-sandrine
- ORCID : 0000-0003-1583-1037
Udo S Gaipl
- Fonction : Auteur
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Olivier Guipaud
- Fonction : Auteur
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Simone Moertl
- Fonction : Auteur
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Georgia I Terzoudi
- Fonction : Auteur
- PersonId : 1111349
Résumé
Various exogeneous and endogenous factors constantly cause damages in the biomolecules within a cell. For example, per day, 10,000–100,000 molecular lesions occur in DNA per cell. The molecule modifications that are formed disturb the structure and function of the affected molecules. The purpose of this chapter is to introduce the damages to biomolecules caused by radiation, the associated repair pathways, and the effect on the cellular function. Special interest lies on the damages induced to DNA, the carrier of the human genome, and the consequence to genomic integrity, cell death, and cell survival. Additionally, related effects regarding inflammation and immunity, epigenetic factors, and omics are discussed. The chapter concludes with an explanation of the molecular factors of cellular hyper-radiosensitivity and induced radiation resistance.
Domaines
Physique Médicale [physics.med-ph]Origine | Fichiers produits par l'(les) auteur(s) |
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