Grids open exciting perspectives to address many of the challenges faced by biomedical research in terms of large scale computing and data management. The e-science group at LPC Clermont-Ferrand focuses on deploying applications and developing services relevant to life sciences and healthcare in grid environments. The group is actively involved in the deployment of large scale distributed applications on the EGEE grid infrastructure. This European project aims at federating distributed resources sharing data and providing a continuity of service using grid technology. As well, the group studies the development of bioinformatics services for complex data management and service discovery using web services within the framework of the RUGBI French inter-regional grid and the EMBRACE European network of excellence. Within the framework of the EGEE project, the team studies the impact of grids for reducing computing time on the GATE Monte-Carlo simulation platform for radiotherapy and brachytherapy and on a wide in silico docking application on malaria. Both applications are distributed in several small jobs which are then deployed on the computing grid. Jobs are submitted by using commands lines developed in the middleware allowing the use of the grid resources (job submission, data management, information system). On both applications, the EGEE infrastructure allows to reach very significant acceleration in computing time, up to a factor 80. The next step is to deploy data management services as well as grid user interface. In the future, a web portal will make it possible for a medical physicist or a bioinformatician to reach the grid resources using an internet connection. For instance, the physicist will be able to store and exploit medical images, to submit and manage jobs, to produce results and to make dose deposit studies.