A recently introduced analytical model for the nuclear density profile[1] is implemented in the Extended Thomas-Fermi (ETF) energy density functional. This allows to (i) shed a new light on the issue of the sign of surface symmetry energy in nuclear mass formulas, which is strongly related to the non-uniformity of the isospin asymmetry in finite nuclei, as well as to (ii) evaluate the in-medium corrections to the nuclear cluster energies in thermodynamic conditions relevant for the description of the (proto)-neutron star crust. The ground state configurations of the model are compared to Hartree-Fock calculations in spherical symmetry for some selected isotopic chains, and systematic errors are quantified. The in-medium modification of the nuclear mass due to the presence of a gas component is shown to strongly depend both on the density and the asymmetry of the nucleon gas. This shows the importance of accounting for such effects in the realistic modelizations of the equation of state for core-collapse supernovae and proto-neutron stars.