The incompressibility of finite fermionic systems is investigated using analytical approaches and microscopic models. The incompressibility of a system is directly linked to the zero-point kinetic energy of constituent fermions, and this is a universal feature of fermionic systems. In the case of atomic nuclei, this implies a constant value of the incompressibility in medium-heavy and heavy nuclei. The evolution of nuclear incompressibility along Sn and Pb isotopic chains is analyzed using global microscopic models, based on both non-relativistic and relativistic energy functionals. The result is an almost constant incompressibility in stable nuclei and systems not far from stability, and a steep decrease in nuclei with pronounced neutron excess, caused by the emergence of a soft monopole mode in neutron-rich nuclei.