We show in this letter that estimates of the local emissivity of {\gamma}-rays in the GeV-TeV range suffer uncertainties which are of the same order of magnitude as the current Fermi results. Primary cosmic-ray fluxes, cosmic-ray propagation, interstellar helium abundance and {\gamma}-ray production crosssections all affect the estimate of this quantity. We also show that the so-called nuclear enhancement factor -- though widely used so far to model the {\gamma}-ray emissivity -- is no longer a relevant quantity given the latest measurements of the primary cosmic ray proton and helium spectra.