A novel differential-input single-output Operational Transconductance Amplifier (OTA) is presented in this paper. The topology proposed consists of an input stage based on a folded cascoded amplifier, and an output stage based on a current source amplifier and a bulk-driven current mirror. The simulations show that the amplifier has a 1.94¹W power dissipation, 92dB open-loop DC gain, a unit gain-bandwidth of 390KHz, a low noise between 537Hz to 390KHz and operates at 0.5V rail-to-rail supply voltage. It was designed for a 0.35¹m CMOS process. The OTA's performance satisfies the required parameters for its implementation in biomedical portable devices.